Brain atrophy in Down syndrome remains the same with age: True or False?

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Multiple Choice

Brain atrophy in Down syndrome remains the same with age: True or False?

Explanation:
Brain aging in Down syndrome is progressive over time, not constant. The combination of developmental differences with age-related neurodegeneration—driven by the APP gene on chromosome 21—leads to increasing brain atrophy as individuals with DS age, especially in regions like the hippocampus and temporal lobes, with ventricular enlargement. This accelerated brain volume loss often aligns with earlier cognitive and functional decline compared with typical peers, meaning the pattern of atrophy changes rather than staying the same. Therefore, the statement is false.

Brain aging in Down syndrome is progressive over time, not constant. The combination of developmental differences with age-related neurodegeneration—driven by the APP gene on chromosome 21—leads to increasing brain atrophy as individuals with DS age, especially in regions like the hippocampus and temporal lobes, with ventricular enlargement. This accelerated brain volume loss often aligns with earlier cognitive and functional decline compared with typical peers, meaning the pattern of atrophy changes rather than staying the same. Therefore, the statement is false.

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