In neuroblastoma, does prognosis typically improve with older age at diagnosis?

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Multiple Choice

In neuroblastoma, does prognosis typically improve with older age at diagnosis?

Explanation:
Age at diagnosis is a strong predictor of outcome in neuroblastoma. Infants, especially those under about 12–18 months, often have tumors with favorable biology, less MYCN amplification, and in many cases a potential for spontaneous regression or excellent response to treatment, leading to better survival. As children are older, the disease more frequently exhibits features tied to higher-risk biology, such as MYCN amplification and unfavorable histology, which are associated with poorer prognosis. So prognosis does not improve with older age; it generally becomes worse as age increases.

Age at diagnosis is a strong predictor of outcome in neuroblastoma. Infants, especially those under about 12–18 months, often have tumors with favorable biology, less MYCN amplification, and in many cases a potential for spontaneous regression or excellent response to treatment, leading to better survival. As children are older, the disease more frequently exhibits features tied to higher-risk biology, such as MYCN amplification and unfavorable histology, which are associated with poorer prognosis. So prognosis does not improve with older age; it generally becomes worse as age increases.

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