Steroids in DMD prolong ambulation by about how long?

• A. 6 months
• B. 3 years
• C. 1 year
• D. 5 years

Answer: (B)

Steroids slow disease progression in Duchenne muscular dystrophy and, on average, delay the loss of independent ambulation by about three years. This benefit comes from medications like prednisone/prednisolone or deflazacort, which help preserve proximal muscle strength, improve function, and can delay contractures and scoliosis, all contributing to a longer period of walking independently. Without treatment, loss of ambulation typically occurs earlier; with steroid therapy, the average extension is around two to three years, making three years the best estimate among the options. Individual responses vary, and some may experience longer or shorter benefit. Be mindful of potential side effects such as weight gain, growth suppression, mood changes, and bone health issues that require careful monitoring.