What happens to muscle tissue in Duchenne muscular dystrophy over time?

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Multiple Choice

What happens to muscle tissue in Duchenne muscular dystrophy over time?

Explanation:
In Duchenne muscular dystrophy, lack of dystrophin makes muscle fibers fragile and prone to repeated injury. This leads to cycles of muscle fiber degeneration and necrosis, followed by inadequate regeneration. Over time, the damaged muscle tissue is replaced by fibrous and fatty tissue, a process called fibrofatty infiltration. This replacement reduces functional muscle and produces pseudohypertrophy, especially in the calves, even as strength rapidly declines. So the key picture is progressive muscle degeneration with necrosis that is ultimately replaced by fibrofatty tissue.

In Duchenne muscular dystrophy, lack of dystrophin makes muscle fibers fragile and prone to repeated injury. This leads to cycles of muscle fiber degeneration and necrosis, followed by inadequate regeneration. Over time, the damaged muscle tissue is replaced by fibrous and fatty tissue, a process called fibrofatty infiltration. This replacement reduces functional muscle and produces pseudohypertrophy, especially in the calves, even as strength rapidly declines. So the key picture is progressive muscle degeneration with necrosis that is ultimately replaced by fibrofatty tissue.

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