Which intervention prolongs ambulation by about three years in Duchenne muscular dystrophy?

• A. Steroids such as prednisone or deflazacort
• B. Physical therapy alone
• C. Surgical interventions only
• D. Vitamin supplements

Answer: (A)

Glucocorticoid therapy is the intervention that most consistently slows progression in Duchenne muscular dystrophy and can extend the period of independent walking by roughly two to three years. Prednisone or deflazacort reduce muscle inflammation and necrosis, help preserve muscle fiber integrity, and maintain strength longer than without treatment. This disease-modifying effect translates into delayed loss of ambulation and also supports better pulmonary function and later scoliosis compared with no steroid treatment. While physical therapy and other measures are important for keeping joints flexible and preventing contractures, they do not provide the same substantial delay in losing the ability to walk. Vitamin supplements or purely surgical approaches lack the evidence to extend ambulation by several years in the way steroids do, though they may play supportive roles in overall care. Keep in mind steroids come with potential side effects like weight gain, growth suppression, and bone health issues, so management includes monitoring and addressing these concerns.