Which palm feature is commonly associated with Down Syndrome?

• A. Double palmar crease
• B. Transverse palmar crease
• C. Normal palmar crease
• D. Simian crease

Answer: (D)

The key idea is a single transverse palmar crease, known as a simian crease, which is a classic minor marker seen more often in Down syndrome. In many children with Down syndrome, the two usual palmar creases fuse into one broad crease that runs horizontally across the palm. This pattern—one transverse crease across the palm—is what clinicians refer to as a simian crease. It’s more common in Down syndrome but not exclusive to it, so it isn’t diagnostic on its own. Other options describe creases that are either not as characteristic (a general transverse crease) or refer to a feature that isn’t typical (two creases or a normal pattern), so the simian crease best fits the association.